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Full therapeutic effects typically develop over 4-12 weeks depending on the severity and type of injury

A clean, sterile environment is paramount to prevent contamination

Conversely, a more recent 16-week randomized controlled trial ( n = 58) reported that sulforaphane (approximately 45 mg/day) failed to change the severity of psychotic symptoms compared to placebo using the total Positive and Negative Syndrome Scale (McGuinness and Kim, 2020)
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These findings, therefore, suggest the potential benefit of low doses of TRZ for treating patients with PDN and support further adequately powered confirmatory trials investigating the efficacy of TRZ
