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However, the iSPN + mut population at 3 months had already impacted numerous marker genes (Extended Data Fig

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SPX proteins regulate Pi homeostasis and signaling in different subcellular level

Inflammatory stimuli upregulate the expression levels of indoleamine 2,3-dioxygenase, which converts tryptophan to immunosuppressive kynurenine metabolites, thereby suppressing pro-inflammatory responses and promoting regulatory T cell proliferation 11

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