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doi: 10.1136/gutjnl-2018-318126 30 KalisperatiPSpanouEPaterasISKorkolopoulouPVarvarigouAKaravokyrosIet al

Researchers have identified one key pathologic component associated with infection severity and course, termed immunothrombrosis

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Activation of these sensors triggers PI3K/Akt signaling and eNOS activation, increasing NO production as well as promotion of nuclear factor erythroid 2-like 2 (Nrf2), responsible for antioxidant gene expression [206]

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