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Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)

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For instance, we also found abnormal connectivity in areas of the anterior temporal network, including the hippocampus and the temporal pole 36

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10.1016/j.ejphar.2020.172953 48 JiangL.KonN.LiT.WangS