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[DOI] [PubMed] 167.Xie YH, Zhang Q, Wang LX, Wang YX, Cheng ZF, Yang ZB, et al

BBB, blood-brain barrier

Patients were randomly assigned to either the high-dose methotrexate arm or the control arm.[4] In the POG-9404 study, patients were also randomly assigned to receive doxorubicin with or without dexrazoxane to determine the efficacy of dexrazoxane in preventing late cardiac mortality.[7][Level of evidence B1] There was no difference in EFS between patients with T-ALL who were treated with dexrazoxane and patients who were not treated with dexrazoxane (cumulative doxorubicin dose, 360 mg/m2).[7] The frequency of grade 3 and grade 4 toxicities that occurred during therapy was similar between the randomized groups, and there was no difference in cumulative incidence of second malignant neoplasms

In one study, GR administration (114.17 mol/kg) brought about antidepressant effects showcased through reduction in immobility frequency in the forced swimming test (FST) and restoring serotonin (5-HT) levels in soluble A 142 (a 42-residue form of A) treated rats (135)

But factors like aging, pollution, stress, and poor diet can deplete its levels

Regarding the aminoalkanoic acid sequence, peroxidases are divided into three classes (Welinder, 1992)