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For patients diagnosed with a vitamin B12 deficiencyespecially when caused by problems with absorption in the digestive tract (such as pernicious anemia, certain gastrointestinal conditions, or after specific surgeries)oral supplements may not be effective

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Once they recovered from thawing, NIM III was replaced with the Astrocyte Induction Medium (AIM) composed of DMEM:F12 base medium with 1% P/S, 2 mM Glutamax, 1% B27 supplement, 1% N2 supplement, 10 ng/ml EGF, and 10 ng/ml LIF

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Results: Injection of FOXO4-DRI in both naturally aged and induced aging mice effectively suppressed aortic aging and improved aortic function

Therefore, during oxidative stress, glutathione depletion enhances ascorbate synthesis to protect against oxidative damage [80]