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doi:10.1016/0014-5793(83)80693-0 [DOI] [PubMed] [Google Scholar] 7.Hatch G

Cluster 4 highly expresses genes related to metabolism (e.g., FAO, OXPHOS), while Cluster 5 exhibits significant chemotactic activity, characterized by high expression of neutrophil chemoattractants (e.g., Cxcl2, Ccl2) and inflammatory pathway genes

Given its simplicity, the hydropersulfide/perthiyl system may represent an evolutionary ancient cellular radical removal system

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Wu Z, Zhang H, Wu M, Peng G, He Y, Wan N, et al

Cellular sensor and signaling hub Lysosomes are key hubs for integrating signals in response to nutrients and energy 37,39
This sets it apart from semaglutide and tirzepatide, which target only one or two of these receptors
