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N = 161,798 after matching GLP-1RA vs diet/exercise consultation Median follow-up: 2 years Key result: Any obesity-associated cancer HR 0.59, 95% CI 0.53-0.67 Site-specific signals: Multiple myeloma HR 0.37 Pancreatic cancer HR 0.40 Endometrial cancer HR 0.42 Colorectal cancer HR 0.49 But remember: This is observational

Conclusion GLP-1RAs show significant promise as a potential disease-modifying therapy for neurodegenerative and inflammatory eye diseases, acting through both systemic metabolic improvements and direct ocular mechanisms, representing a paradigm shift beyond their metabolic indications.

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In this study we investigated the target occupancy of the dual agonist SAR425899 at the GLP1R in pancreas and GCGR in liver by Positron Emission Tomography/Computed Tomography (PET/CT)