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Most therapeutic interventions remain in preclinical development, with clinical translation hindered by two key barriers: The lack of validated biomarkers for patient stratification and incomplete elucidation of synergistic combination mechanisms
The red-pigmented nutrient is most often found in red fruits and vegetables
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Mix C4-C24 (Supelco, Bellafonte, PA, USA) and relevant references 96,97
The k -NN algorithm facilitated an iterative labelling process by classifying regions with robust historical incidence or prevalence data into one of three classifications: stage 1, stage 2 or stage 3
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