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1 Introduction The pathogenesis of autoimmune type 1 diabetes mellitus (T1D) involves infiltration of the pancreatic islet cells by T-lymphocytes, macrophages, and other immune cells with consequent loss of insulin producing -cells ( Outside of the CNS, GABA is highly concentrated in the pancreatic islet wherein it has autocrine and paracrine actions to regulate -cell insulin secretion and inhibit -cell glucagon release

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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Czonkowska A, Litwin T, Dusek P, Ferenci P, Lutsenko S, Medici V, Rybakowski JK, Weiss KH, Schilsky ML

In these studies, participants with obesity achieved up to a remarkable 24.2% mean body weight reduction at 48 weeks

10.1194/jlr.R067520 35 JiaJ.Claude-TaupinA.GuY.ChoiS