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It is also important to note that PZQ resistant strains can be generated in laboratory conditions and observed in the field, hence its extensive use in mass drug administration programs raises concerns about resistance, highlighting the need to search for new schistosomicidal drugs

Yu LJ, Zhang KJ, Zhu JZ, Zheng Q, Bao XY, Thapa S, et al

There is no gold standard for treatment, and most patients use various medications from a number of classes to relieve their pain

The synthesis of branched-chain fatty acids is limited by enzymatic decarboxylation of ethyl- and methylmalonyl-CoA

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Rosas-Ballina M, Guan XL, Schmidt A, Bumann D

However, like many polymeric carriers, their intrinsic ability to cross the BBB is limited without functional modification
