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Description

A divalent interaction between HPS1 and HPS4 is required for the formation of the biogenesis of lysosome-related organelle complex-3 (BLOC-3)

To facilitate further high-throughput annotation of oxGPLs, we compiled our results obtained by MS3 and elevated energy stepped HCD MS2 fragmentation of selected oxylipin standards and in vitro oxidized PC lipids (Supplementary Data 1.1 and 1.2), literature data on the fragmentation of oxidized free fatty acids and complex lipids 20,22,26,27,28,29,30,31,32,33,34 , as well as available MS2 spectra from METLIN, LIPID MAPS, and MS DIAL.msp library, in the form of fragmentation rules exemplified here for different modification types and positions on oxidized oleoyl (18:1), linoleoyl (18:2), and arachidonoyl (20:4) chains in PC lipids (Supplementary Data 2)

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In 2019, Big shocked This Morning viewers when she revealed that she expected her future children to be born with dark skin, despite her and husband Michael both being born white