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Description
Epilepsy in Biotinidase Deficiency After Biotin Treatment
It serves as the main gateway for electron entry into the ETC and is the primary site for regeneration of NAD +
Nat Med 32 , 883893 (2026)
& Ge, J
This hydrolysis is carried out by the enzyme adenosylehomocysteinase (AHCY)
Confocal microscopy revealed a pronounced nuclear-to-cytoplasmic translocation of HMGB1/2-GFP following Hcy or HTL exposure (Figure 5B), with extracellular fluorescence intensity quantification further confirming increased HMGB1/2 secretion (Figure 5C)
