glutathione biofilm The pathway is required for formation in Acinetobacter baumannii Targeted metabolomics analysis approach to

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doi:10.1016/j.enzmictec.2016.08.004 Lu SC (2009) Regulation of glutathione synthesis

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1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])