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Discussion Hepatocyte death is one of the primary features of NASH, the progressive form of NAFLD 3

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250252 Biological Assays for the Identification of NOX Inhibitors The evaluation of the activity of potential NOX inhibitors is generally performed by applying different enzymatic assays based on the measurement of substrates (i.e., NADPH or O 2 ) and/or reactive oxygen species (i.e., superoxide anion and H 2 O 2 ) that are consumed and/or generated by NOX proteins

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This impaired conversion may lead to tissue-specific hypothyroidism not captured by standard thyroid function tests

IRI is a critical concern in a variety of clinical scenarios, most notably in acute myocardial infarction, ischemic stroke, and organ transplantation, where timely restoration of blood flow is both life-saving and potentially injurious