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Tetrahedron Lett

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Haesebrouck, F

BioMed Pharmacother (2019) 118:109249

[167] [168] According to a Cochrane review on withdrawal in individuals who compulsively use amphetamine and methamphetamine, "when chronic heavy users abruptly discontinue amphetamine use, many report a time-limited withdrawal syndrome that occurs within 24 hours of their last dose." [169] This review noted that withdrawal symptoms in chronic, high-dose users are frequent, occurring in roughly 88% of cases, and persist for 34 weeks with a marked "crash" phase occurring during the first week