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Neuroimaging studies (Wen et al., 2024) have shown that patients with EDC often exhibit hippocampal atrophy, amygdalar volume abnormalities, and disrupted prefrontal-limbic connectivity, indicating impairment of emotion-regulation-related neural networks

Oxidative stress and inflammation in the evolution of heart failure: From pathophysiology to therapeutic strategies

Individual Variability : Factors such as age, overall health, and the presence of other medical conditions can significantly influence an individuals response to B12 deficiency treatment, as well as the duration of their recovery

doi: 10.1111/j.1464-5491.2005.01574.x

This was noted in counteraction of rat occlusion/occlusion-like syndromes as an activation of the collateral-rescuing vascular pathway [1]

The mechanisms by which long-term hyperglycemia induces cardiomyopathy in DM include at least three key aspects: 1) hyperglycemia-induced oxidative stress promotes the excessive release of reactive oxygen species, which in turn induces cardiomyocyte apoptosis, 2) the oxidative stress may also result in persistent inflammatory damage to blood vessels, thereby increasing the risk of diabetic cardiomyopathy, and 3) hyperglycemia adversely affects protein structure