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This explains the reason for decreased levels of GSH and the consequences related to the GSH deficiency such as loss of immune function observed in HIV patients ( Figure 4 )

Endogenous purines primarily originate from dead cells, and mitochondrial dysregulation leads to an accumulation of purines

Annals Rheumatic Dis

Funding Publication of this supplement has been supported by AstraZeneca, Boehringer Ingelheim, CSL Behring Canada Inc., MEDA Pharmaceuticals Ltd., Merck Canada Inc., Pfizer Canada Inc., Shire Pharma Canada ULC, Stallergenes Greer Canada, Takeda Canada, Teva Canada Innovation, Aralez Tribute and Pediapharm

& Genicot, C

[DOI] [PubMed] [Google Scholar] Varis K, Salmi HA, Siurala M