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Research confirms that Pycnogenol enhances endothelial NO production by increasing endothelial nitric oxide synthase (eNOS) activity and protects the generated NO from degradation by scavenging superoxide anion radicals, thereby improving its bioavailability (250)

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Van Dam EW, Roelfsema F, Helmerhorst FH, Frlich M, Meinders AE, Veldhuis JD, Pijl H
Contributes to a broader understanding of cellular signalling pathways

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That difference is a significant, sometimes dramatic shift for peptide stability