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10.1038/384173a0 Nature 202 XinX.YangS.IngleG.ZlotC.RangellL.KowalskiJ.et al (2001)

Daniel Culver of the Cleveland Clinic, stated that the magnitude of effect in only 28 days was remarkable and suggested cibinetide has the potential to become a transformative disease-modifying therapy

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This notion is supported by observations that monoamine reuptake inhibitors, including dual norepinephrine/serotonin and norepinephrine/dopamine reuptake inhibitors, produce combined effects on both feeding behavior and metabolic rate through complementary mechanisms
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This is in concordance with past evidence noting significant degradation of full-length tubulin- with increased post-mortem interval in human brain, as well as similar findings noted in other biological samples such as bone and skeletal muscle 37,38
