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Under physiological conditions, Nrf2 remains sequestered in the cytoplasm by its inhibitor, the Kelch-like ETC-associated protein 1 (Keap1), but oxidative or electrophilic stress triggers Nrf2 dissociation, nuclear translocation, and binding to antioxidant response elements (AREs), upregulating genes such as heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutathione S-transferases (GSTs) (Cuadrado et al., 2019)

[DOI] [PubMed] [Google Scholar] 79.Lucock M., Jones P., Martin C., Beckett E., Yates Z., Furst J., Veysey M

ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

This remarkable molecule works quietly behind the scenes, protecting every cell, supporting detoxification, and even helping other antioxidants do their job better

Baseline Annexin V expression was significantly elevated (81.00 1.5), indicating increased apoptotic activity and cellular stress in the hematopoietic-endothelial compartment ( Figure 1A )
