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Pathological examination revealed that the organ index of the brain increased, the water content and Evans blue content in the brain tissue decreased, and the neuronal structure in the CA3 region of the hippocampus was relatively normal, with abundant organelles, clear nuclear membranes, and normal mitochondrial morphology (Fei et al., 2015)

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Interestingly, the decrease in sorbitol dehydrogenase (SDH), which plays a key role in the maturation of the germinal epithelial layer of the seminiferous tubule, combined with the increase in lactate dehydrogenase (LDH), supports the hypothesis of damage to the germinal epithelium (Alboghobeish et al., 2019)

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