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Les travaux de Sekhar et collaborateurs ont par ailleurs identifi que cette dficience chez les personnes ges provient d'une synthse insuffisante, lie notamment un manque de disponibilit des acides amins prcurseurs (glycine et cystine)

Moloney AM, Griffin RJ, Timmons S et al (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimers disease indicate possible resistance to IGF-1 and insulin signalling

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For instance, extracts from Guizhi Fuling Pills and Paeonia bark gum (Baikejiao) have been reported to downregulate transferrin receptor 1 (TfR1) and upregulate ferroportin 1 (FPN1) expression, thereby facilitating the restoration of intracellular and extracellular iron equilibrium (Liu R