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The review also covers the mechanisms linking the astrocyte cytoplasmic [NADPH]/[NADP + ] and [NAD + ]/[NADH], as these two redox couples are frequently coupled, being reduced or oxidized together

S., Johnson, L

ACS Nano 13 , 386398 (2019)
GHK-Cu also modulates over 4,000 human genes, suppressing IL-6 and TNF-alpha while stimulating antioxidant defenses (Pickart & Margolina, 2018)

HAT reactions are independent of solvent and pH and are usually very fast, typically completed within seconds to minutes

Thus, a huge literature supports the effect of abiotic stress on secondary metabolite production
