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Elevated intestinal SCFA levels during pregnancy have been associated with a reduced risk of inflammation-related spontaneous preterm birth, likely by preserving intestinal epithelial integrity and attenuating the delivery pathway triggered by bacterial translocation and endotoxin-induced inflammatory mediators and prostaglandins 275,278

Notably, similar to the lack of effect on mitophagy or mitochondrial morphology observed with DNA-PKcs knockdown (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Ruchko MV, Gorodnya OM, Zuleta A, Pastukh VM, Gillespie MN

A., Cruz-Morales P., Marcellin E., Capon R

Conversely, the early-stage autophagy inhibitor 3-MA partially attenuated KU-mediated LC3-II activation