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e , Immunoblot of GTP-bound KRAS Q61H by RBD pull-down assay in STR (250 nM) or SHP099 (500 nM) treated in H460 cells

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Peripheral inflammatory cytokines can enter the CNS through the blood-brain barrier (BBB) or specific transporters [64]

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Other mitochondrial dysfunction mechanisms in patients suffering from ME/CFS include AMPK-altering protein recycling and fatty acid catabolism, mTORC1, and creatine kinase altering cell cycle and instability across different tissue and cell types (Khan et al., 2017