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Serena Williams was one of the many celebrities featured in a Super Bowl ad, but she may have received the most backlash.

The medication's success underscores the value of targeting incretin pathways in treating metabolic disorders and highlights the chronic nature of conditions like obesity that benefit from ongoing management rather than short-term interventions

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Here we review evolving concepts of incretin action, focusing predominantly on GLP-1, from discovery, to clinical proof of concept, to therapeutic outcomes

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