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Thus, despite the growing advocacy for ozone therapy as a versatile and efficient treatment modality in chronic pain management, its broad clinical application demands further empirical rigour

In some cases, the cell can compensate for mitochondrial damage and refresh its mitochondrial network, whereas in other cases, the cell will clear the damaged mitochondria by mitophagy or cell death will occur

10.1007/s10096-020-03912-w [DOI] [PubMed] [Google Scholar] 151.Singh DK, Nmeth T, Papp A, Tth R, Lukcsi S, Heidingsfeld O, et al

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10.1016/s0009-8981(03)00200-6 Clin Chim Acta

A destruction of the cristae of the inner mitochondrial membrane has also been described in PLAN (Table 1) fibroblast patients [154], which can lead to the total degeneration of the organelle