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Examination of the isotopomer distributions for TCA cycle metabolites showed a significant decrease in the percentage of citrate M5 upon glucose deprivation, indicating decreased reductive carboxylation flux from -ketoglutarate to citrate in glucose-deprived cells 28, 29 (Fig

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However, MenSCs display a significantly faster proliferation rate, with a population doubling time of approximately 19.4 hoursroughly twice as fast as that of bone marrow-derived MSCs (BM-MSCs) (Skliut et al., 2021)