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In contrast, for those diseases caused by NRF2 loss of function or a defect in one of the NRF2-regulated pathways, reactivating an alternative pathway that could also contribute to ROS detoxification might be a way to resolve the problem

The intervention produced no significant improvement in severity or frequency of aberrant behaviors during treatment or follow-up (Politi et al., 2008)

10.1016/j.bbrc.2011.11.047

B: Inhibition of PKA prevents the high glucose-induced increase in NADPH oxidase activity
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10.1016/j.jot.2025.05.006 127 ZhaoX.HuangH.JiangX.ZhengS.QiuC.ChengY.et al (2025b)

5 Uncovering novel mechanisms with multimodal and multi-omics AI 5.1 Multimodal data fusion: integrating clinical, imaging, and omics data The integration of multimodal artificial intelligence models with different data types provides a promising path for precision medicine, which can better predict the future cardiovascular event risk of MASLD patients
