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Thymalin's mechanism is more conventional than the short-peptide DNA-binding theory, as thymic peptide extracts have well-characterized immunomodulatory properties recognized internationally (thymosin alpha-1, for example, is a single thymic peptide with global clinical use)

J Basic Microbiol 51:183190

Consistent with this, transfection with adeno-associated virus expressing short hairpin RNA of Usp2 (AAV-sh Usp2 ) decreased the protein level of TGFBR1 in the kidney of WT mice compared to those transfected with AAV-Ctrl (Fig

Supplementary material The Supplementary Material for this article can be found online at: FIGURE S1 Growth of wild-type strain CAUH2 and the mutants CAUH2copR, CAUH2copB, and CAUH2melA

After 24 h, BrdU was added to the cell culture medium for 4 h, whereafter cells were fixed, DNA was denatured and anti-BrdU antibody conjugated to peroxidase was added
