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The answers are not what most people want to hear, but they are important to understand before starting therapy, while you're on it, and especially if you're considering stopping

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Ex vivo scans and histology were also carried out to further confirm the PET-imaging findings (unpublished data)

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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis