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When these plaques eventually rupture and break off, they can clog your blood vessels and block blood flow that causes heart attacks or strokes

Components of the extrinsic pathway include the death receptors FasR/FasL, DR4/DR5, and tumor necrosis factor (TNF) [20], whereas the intrinsic pathway centers on the Bcl-2 family of proteins which comprises both proapoptotic proteins, such as Bax, Bak, and Bid and antiapoptotic proteins, such as Bcl-2 and Bcl-xL [18, 19]

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Consequently, IGF-1 LR3 has improved potency and metabolic stability [5]

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