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Because it modulates cellular NAD+ availability and mitochondrial function, some protocols administer it in the morning to align peak NNMT inhibition with waking metabolic activity

Everything else ranges from marginally helpful to completely unproven

10.3389/fnagi.2010.00012 205 WangX.PalR.ChenX

Elevated expression of the PKM2 isoform has been correlated, in numerous cancers, to a hypomethylated state in intron 1 of the PKM gene

Assignment of the human -glutamyl transferase gene to the long arm of chromosome 22