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Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome Mol Cell Proteomics 15 2: 445-61

The ultimate therapeutic dose should be achieved on the basis of both tolerability and clinical response [see Warnings and Precautions(5.16), Use in Specific Populations (8.5), and Clinical Pharmacology(12.3)]

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It is recommended to make breaks in prolonged periods of use.

Patano and colleagues suggest that this decrease in energy availability might compromise osteoblast activity and bone remodeling in an age-related manner [152]