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Our in vivo studies further highlight the pivotal role of GR in pathogen fitness

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Secretion of IL-8 by Tregs that are enriched in malignant pleural effusions induces TAMs to produce TGF-, which subsequently mediates c-Fos to regulate CCL22 secretion and further promotes Tregs recruitment, forming a vicious circle that promotes the development of an immunosuppressive microenvironment (228)