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Importantly, the triple-helix conformation demonstrates superior radical-quenching efficacy, with significantly elevated antioxidant activity across standardized assays: DPPH (IC 50 = 2.498 mg/mL), ABTS (IC 50 = 3.413 mg/mL), FRAP (44.73 2.88 mol Fe 2+ /g), and ORAC (47.09 5.68 mol TE/g)

Kroner et al (49) demonstrated that elevated iron levels in microglia promote phagocytosis and drive a harmful M1 phenotype, which triggers the release of pro-inflammatory factors such as TNF-, IL-1, IL-6 and nitric oxide (NO), causing neuronal damage

Yang YP, Cherian MG

Cai, W., Luo, T., Chen, X., Mao, L

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Free Rad Biol Med 2012;52(10):2128-2141