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This dysregulation contributes to systemic inflammation, insulin resistance, and vascular dysfunction

attempted to prevent hepatotoxicity in massive APAP overdoses by doubling the rate of NAC infusion over the last 16 hours, giving patients 12.5 mg/kg/h instead of the standard 6.25 mg/kg/h

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Thus, the ascorbate-glutathione pathway was assigned a key function in the metabolism of hydrogen peroxide in the chloroplasts (Foyer and Halliwell, 1976) while glutathione became implicated in stress resistance in general (Esterbauer and Grill, 1978

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