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Similarly, inflammatory cytokine IL-6 (148) also acts on gut endocrine L cells to promote GLP-1 secretion

GLP-2(Tirz) Dual GIP/GLP-1 Receptor Agonist: For researchers studying dual incretin amplification, GIP receptor contribution to metabolic outcomes, and the established 20-22% effect magnitude ceiling of dual agonism

However, the indirect interactions through delayed gastric emptying , enhanced insulin action, and GI side effect amplification create meaningful clinical risks that warrant caution

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