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Bromelain exerts a profound anti-inflammatory effect by actively modulating the signaling pathways that drive this tissue damage

When the early signal also happened to favor a lower dose over a higher one an inverted dose-response that is a classic warning sign of noise rather than a true pharmacological effect the case for genuine efficacy was already fragile before the pivotal trial delivered its verdict

J Clin Psychiatry 2000;61:868-71

Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system

In these patients, the translocation of gut-derived endotoxins, such as lipopolysaccharides (LPS), into systemic circulation is a recognized contributor to systemic inflammation and subsequent BBB compromise (Sonneville et al., 2023)