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Low-grade neuroinflammation as indexed by heightened levels of pro-inflammatory mediators (e.g., TNF-, IL-1, and COX-2) and activation of astrocytes and microglia, main immune cells in the brain, was observed in the hippocampus and piriform cortex regions of the brain of chronic sleep-deprived rats along with neurobehavioral alterations (anxiety, learning, and memory impairments) 136

But it really does help negate the inflammation and the insulin insensitivity that can happen after even just a single night of sleep

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Takiishi T, Cook DP, Korf H, Sebastiani G, Mancarella F, Cunha JP, Wasserfall C, Casares N, Lasarte JJ, Steidler L, Rottiers P, Dotta F, Gysemans C, Mathieu C (2017) Reversal of diabetes in NOD mice by clinical-grade proinsulin and IL-10-secreting Lactococcus lactis in combination with low-dose anti-CD3 depends on the induction of Foxp3-positive T cells

The results showed a statistically significant difference in fat loss between AOD-9604 and placebo, but the magnitude was modest