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Purpose To investigate the integrated therapeutic benefits of the phytopharmaceutical berberine and mucoadhesive nanoliposomes, administered via the nose-to-brain route, to enhance bioavailability, facilitate blood-brain barrier penetration, and augment efficacy against neurodegenerative progression in Parkinsons disease (PD)

However, limitations include in vivo instability, reliance on biocompatible and robust carriers and restricted application procedures (local and direct)

In the present study, we found that STAG2 was frequently down-regulated in thyroid cancers compared with control subjects

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Further analysis identified ferroptosis sensitivity as a major determinant of APR-246 sensitivity