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Further, the use of lipase PS or CRL (Amano) can also provide good results, instead of Novozyme 435

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The area treated during microneedling may have pin-point bleeding during the procedure

A 0.4 mL/min linear gradient elution was used: 01 min, 9075% solvent B, 12 min, 7565% solvent B, 24 min, 6555% solvent B, 45 min, 5540% solvent B
