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Description
In the absence of intracellular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) not only reacts with nucleophilic groups of cellular proteins resulting in direct hepatocellular damage, but also participates in redox cycling, thereby generating reactive O 2 species ( ROS ) and consequent oxidative stress that greatly enhance APAP-induced hepatotoxicity

British journal of haematology, 14(6), 575-592

The platinum chemistry could be performed on the solid support and the complex survived the deprotection and cleavage reactions

Cancer Manag Res 12:397409

RoseSMelnykSTrustyTAPavlivOSeidelLLiJet al

promote selective importation of mitochondrial proteins
