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PMID: 33288274, DOI: 10.1016/j.leukres.2020.106478

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219223 While reductions in oxygen consumption can maintain whole-kidney oxygenation when renal artery stenosis is moderate, this compensatory mechanism becomes overwhelmed when vascular occlusion reaches between 70% and 80%

Cancer Res 69: 27752782 Sanyal AJ, Yoon SK, Lencioni R (2010) The etiology of hepatocellular carcinoma and consequences for treatment

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A single FOXO4-DRI dose clears accessible senescent cells within the circulation and tissues with high vascular permeability, but deeper tissue reservoirs require time for macrophage-mediated clearance of apoptotic material before a second dose can access previously shielded senescent populations