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Iron homeostasis, complement, and coagulation cascade as CSF signature of cortical lesions in early multiple sclerosis
Influence of Co-Mutational Patterns in Disease Phenotype and Clinical Outcomes of Chronic Myelomonocytic Leukemia

Generally, NNMT activity or expression is significantly elevated in cancers, such as brain [68], lung [69], liver [70], kidney [71, 72], bladder [73], stomach [74, 75], pancreas [76], colon [77], and oral [78, 79] cancer but cancer cells usually have a significantly higher anaerobic metabolism rate than normal cells
Currently, biologic medicines represent only about 5% of prescriptions in the U.S

Besides this, ROS can also regulate the expression of multiple tumor suppressor genes like p53, Nrf2, PTEN, and Rb (Gupta et al., 2012)

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