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J Mol Cell Cardiol 48:757764 [DOI] [PMC free article] [PubMed] [Google Scholar] Budas GR, Disatnik MH, Mochly-Rosen D

This article demonstrates a link between MSI and the expression of immune checkpoint molecules in the TME, providing multiple therapeutic targets for MMR-defective colorectal carcinomas

In phase I, a explorative, single-blind, placebo-controlled study [260] was conducted to assess the safety, tolerability, and preliminary pharmacokinetics of BPC 157 in thirty-two healthy male volunteers (A placebo-controlled study to investigate the safety, tolerability and preliminary pharmacokinetics of PL 14736 in healthy male subjects

Peptide therapy is less likely to cause the side effects related to non-specific immune suppression drugs usually prescribed for autoimmune disease, such as constipation, diarrhea, or an increased risk of infection

Hypoxic conditions within tumors stimulate angiogenesis by upregulating hypoxia-inducible factor-1 (HIF-1), which in turn induces the production of vascular endothelial growth factor (VEGF)

re-assess as needed, with some extending to ~12 weeks with periodic breaks
