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The freeze-thaw cycle can damage the delicate peptide structure, a process called denaturation, which can reduce its effectiveness

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However, in the case of the BPC 157 peptide, the above-mentioned structural features have not been reported

71 The PEGylated liposome displayed statistically improved uptake and retention time after intranasal administration compared to administration of the free drug solution, using a human organotypic nasal explant under simulated mucociliary clearance conditions

This is likely due to the role of vitamin B12 in energy production and metabolism

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