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The trial is open-label and single-arm (without a placebo group), with participants receiving a single intracerebroventricular dose

Furthermore, in the gastrocnemius muscle of SOD1 G93A mice, the activities of the TCA cycle enzyme 2-oxoglutarate dehydrogenase (OGDH) were found to be reduced in the late symptomatic phases of the disease, indicating impairments in the TCA cycle pathway (Tefera et al., 2016)

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Poor blood flow to the brain