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GSH serves as a nucleophilic co-substrate of detoxification enzymes such as glutathione S-transferases (GST) in detoxifying xenobiotics 5,6

Therefore, there is a growing interest in determining the best method(s) to increase cellular glutathione for both disease prevention and treatment

However, as discussed further below, there is evidence that highly efficacious MOR agonists can engage other mechanisms of phosphorylation and desensitization

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